+91-9818 456 444  admin@inphog.org

Logo
Donate Now

InPOG-HL-19-03

Response-Adapted Management of Childhood Classical Hodgkin Lymphoma (cHL) and Early Response Assessment by Positron Emission and Computerized Tomography (PET-CT) to allow Omission of Radiotherapy in Indian Children with Treated with a Standard of Care Intensified Chemotherapy Regimen.

PI : Dr. Gaurav Narula

Institution : Tata Memorial Hospital, Mumbai

Mail Id :drgauravnarula@gmail.com

About the Study

Evaluates a response-adapted treatment approach in children with Classical Hodgkin Lymphoma (cHL), using early PET-CT scans to guide therapy. The study explores whether radiotherapy can be safely omitted in children who show a good early response to chemotherapy, with the goal of reducing long-term side effects while maintaining effective treatment outcomes.

Aim of the Study
  • RCT Arm : Primary objective is the feasibility of elimination of RT in childhood cHL with bulky disease and adequate response on early PET-CT based response assessment after 2 cycles OEPA by looking at Event free survival.
  • Descriptive Arm : Primary objective is to assess the Event free survival of cHL treated on standard risk-adapted protocols across multiple paediatric oncology centres in India.
Eligibility Criteria
Inclusion Criteria
  • Children ≤18 years of age.
  • Newly diagnosed Biopsy proven cHL.
  • Adequate response on Early Response Assessment PET-CT after 2 cycles OEPA in baseline bulky disease (to be eligible for randomization in RCT arm).
  • Written Informed consent approved by local ethics committee from patient ‘s parents or guardia.
Exclusion Criteria
  • Previous treatment with chemotherapy (except for steroid in case of symptomatic mediastinal mass and pre-enrolment chemotherapy in RCT arm).
  • Previous immunotherapy or radiotherapy or participation in another investigational trial.
  • Other malignancies- on previous history or simultaneous.
  • Severe concomitant diseases (e.g., immunodeficiency) (exclusion only for RCT arm).